Will this radiator work with my manual transmission car?

This is built specifically for automatic transmission applications—it includes the integrated transmission cooler circuits. Manual cars need a different core without those passages.

Do I need to drain my coolant before pulling the old radiator?

Yes. You'll lose coolant when you disconnect hoses and remove the old unit. Plan for fluid disposal and have fresh coolant ready for the refill.

Does this come with new hoses and clamps?

The radiator core ships without hoses or clamps. Reuse your existing ones if they're in good shape, or source new hoses separately to be safe.